MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC 50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs).In VitroMLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid.
Specifications and Purity: ≥99%
Molecular Formula: C16H11FN4O2S
Molecular Weight: 342.35
- UPC:
- 41113643
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M646706-10mg
- CAS:
- 862975-18-6
- Product Size:
- 10mg
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