ML148 is a potent and selective 15-PGDH inhibitor with an IC 50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathwaysIn VitroML148 (compound 13) shows selectivity with IC 50 s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively. ML148 (10, 20 nM) decrease V max by 25% and reduces the apparent K m by half at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC 50 : 56 nM (15-PGDH).
Specifications and Purity: ≥99%
Molecular Formula: C20H21N3O
Molecular Weight: 319.4
PubChem CID: 3243760
Isomeric SMILES: CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4
- UPC:
- 41103816
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M647091-25mg
- CAS:
- 451496-96-1
- Product Size:
- 25mg
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