MITOMYCIN C

General description

Mitomycin C is an antitumor antibiotic.

Application

Mitomycin C has been used:

• to cease mitosis
• in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
• as mutagen in mutagenicity assay

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.

Biochem/physiol Actions

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Molecular Weight: 334.33. Empirical Formula: C₁₅H₁₈N₄O₅. Quality Level: 100. Assay: 98%. form: crystalline powder. mol wt: 334.3. packaging: pkg of 2 . mg. manufacturer/tradename: Roche. antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria. Mode of action: DNA synthesis | interferes. storage temp.: 2-8°C. InChI: 1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1. InChI key: NWIBSHFKIJFRCO-WUDYKRTCSA-N. Pictograms: GHS06,GHS08. Signal Word: Danger. Hazard Statements: H300 - H351. Precautionary Statements: P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501. Hazard Classifications: Acute Tox. 2 Oral - Carc. 2. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): does not flash. Flash Point(C): does not flash.