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microsomes from liver, pooled (c15-1891-925)

MICROSOMES FROM LIVER POOLED FROM HUMAN MALE TISSUE (C005B-455065)

Catalog No.
C005B-455065
Manufacturer No.
M0567-1VL
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
VL

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Application Microsomes from Liver, Pooled has been used: in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process as a human liver microsomes (HLM) matrix for testing metabolic stability of

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Application

Microsomes from Liver, Pooled has been used:

  • in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
  • as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
  • to study the metabolization of enantiomeric peptide D3

Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.

UPC:
12161701
Condition:
New
HazmatClass:
No
MPN:
M0567-1VL
Temperature Control Device:
Yes

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