MGR1 (C005B-309814)

Catalog No.: C005B-309814
Manufacturer No.: SML2953-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Biochem/physiol Actions MGR1 is an effective reactive oxygen species (ROS) generator in live cells (dosing range 2-100 μ:M). MGR1 is activated by intracellular esterases to form JCHD

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Description
Specifications

Biochem/physiol Actions

MGR1 is an effective reactive oxygen species (ROS) generator in live cells (dosing range 2-100 μM). MGR1 is activated by intracellular esterases to form JCHD (5-hydroxy-1,4,4a,9a-tetrahydro-1,4-ethanoanthracene-9,10-dione), which in turn, facilitated by a proximal H-bonding hydroxyl group, undergoes keto-enol tautomerism for enhanced superoxide (O2â€¢-) generation upon reacting with molecular oxygen (O2). MGR1, but not its inactive analog MGR2, upregulates cellular ROS, resulting in cell death when used at high concentrations (>5 μM; RAW264.7, THP1, HeLa, MCF7, A549).

UPC:: 41113404
Condition:: New
HazmatClass:: No
MPN:: SML2953-25MG
CAS:: 2361529-46-4

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