MG-132(R)

Catalog No.: C005B-312500
Manufacturer No.: SML1135-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions MG-132(R) is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells at 10 M.

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Description
Specifications

Biochem/physiol Actions

MG-132(R) is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells at 10 M. MG-132(R) blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. However, MG-132(R) also activates c-Jun N-terminal protein kinase (JNK-1), which initiates apoptosis in response to cell stress. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types.

Legal Information

SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC

UPC:: 12141502
Condition:: New
HazmatClass:: No
MPN:: SML1135-5MG
CAS:: 1211877-36-9

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