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methotrexate hydrate (c15-1889-957)

METHOTREXATE HYDRATE POWDER BIOREAGENT SUITABLE FOR CELL CULTURE >=98% (HPLC) (C005B-453333)

Catalog No.
C005B-453333
Manufacturer No.
M8407-500MG
Manufacturer Name
Sigma-Aldrich
Quantity
500
Unit of Measure
MG

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Application Methotrexate hydrate has been used: as a dihydrofolate (DHFR) :inhibitor in sphere forming assay culture as a component of dulbecco′: modified Eagle′:s medium (DMEM) for selection of transfected cells in

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Application

Methotrexate hydrate has been used:

  • as a dihydrofolate (DHFR) inhibitor in sphere forming assay culture
  • as a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cells
  • in viability and co-culture assays

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Biochem/physiol Actions

Methotrexate is a folic acid antagonist.

Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.

UPC:
51191518
Condition:
New
HazmatClass:
Yes
MPN:
M8407-500MG
CAS:
133073-73-1

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