InformationBPN14770 is a selective allosteric inhibitor ofphosphodiesterase 4D (PDE4D)with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.TargetsPDE4D3 (Cell-free assay): PDE4D7 (Cell-free assay) 7.4 nM: 7.8 nM.
InformationBPN14770 is a selective allosteric inhibitor ofphosphodiesterase 4D (PDE4D)with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.TargetsPDE4D3 (Cell-free assay): PDE4D7 (Cell-free assay) 7.4 nM: 7.8 nM.
CP-55940 is a cannabimimetic small molecule and a potent cannabinoid receptor agonist, demonstrating similar binding activity at both receptor types (CB1 K|i|=0.58 nM, CB2 K|i|=0.69 nM). CP-55940 represents a useful non-selective agonist entry into
CP-55940 is a cannabimimetic small molecule and a potent cannabinoid receptor agonist, demonstrating similar binding activity at both receptor types (CB1 K|i|=0.58 nM, CB2 K|i|=0.69 nM). CP-55940 represents a useful non-selective agonist entry into
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC 50 value of 7 nM for hu mGluR7 . CVN636 has central nervous system (CNS) permeabilityIn VivoCVN636 (0.3-3 mg/kg: p.o.) reduces ethanol self-administration in msP
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC 50 value of 7 nM for hu mGluR7 . CVN636 has central nervous system (CNS) permeabilityIn VivoCVN636 (0.3-3 mg/kg: p.o.) reduces ethanol self-administration in msP
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC 50 value of 7 nM for hu mGluR7 . CVN636 has central nervous system (CNS) permeabilityIn VivoCVN636 (0.3-3 mg/kg: p.o.) reduces ethanol self-administration in msP
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC 50 value of 7 nM for hu mGluR7 . CVN636 has central nervous system (CNS) permeabilityIn VivoCVN636 (0.3-3 mg/kg: p.o.) reduces ethanol self-administration in msP
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC 50 value of 7 nM for hu mGluR7 . CVN636 has central nervous system (CNS) permeabilityIn VivoCVN636 (0.3-3 mg/kg: p.o.) reduces ethanol self-administration in msP
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC 50 value of 7 nM for hu mGluR7 . CVN636 has central nervous system (CNS) permeabilityIn VivoCVN636 (0.3-3 mg/kg: p.o.) reduces ethanol self-administration in msP
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC 50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC 50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central