Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC 50 s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).Form:SolidIC50& Target:Protease Cleavable Cleavable.
Molecular Formula: C28H39ClN6O6
Molecular Weight: 591.10
PubChem CID: 117719308
Isomeric SMILES: CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CCl)NC(=O)CCCCCN2C(=O)C=CC2=O
- UPC:
- 42203501
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M650176-100mg
- CAS:
- 1639351-92-0
- Product Size:
- 100mg
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