MC-GGFG-Exatecan (C007B-374544)

MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)In VitroIn MC-GGFG-Exatecan, GGFG is selectively cleaved by lysosomal enzymes (presumably cathepsins). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn MC-GGFG-Exatecan, GGFG is known to release drugs into tumor tissue without releasing them into peripheral circulation . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Camptothecins.

Specifications and Purity: ≥99%

Molecular Formula: C49H51FN8O11

Molecular Weight: 946.97

PubChem CID: 118567450

Isomeric SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)CNC(=O)[C@H](CC7=CC=CC=C7)NC(=O)CNC(=O)CNC(=O)CCCCCN8C(=O)C=CC8=O)O