Malic enzyme inhibitor ME1 (C007B-374842)

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC 50 of 0.15 μMIn VitroMalic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72?hours) shows a significant reduction in total cell numbers. ?/nMalic enzyme inhibitor ME1 shows a significant reduction in cell viability/metabolic activity in MTS cell. ?/nMalic enzyme inhibitor ME1 dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 and HT29 cell line Concentration: 50 μM Incubation Time: 72 hours Result: Showed a significant reduction in total cell numbers.Form:SolidIC50& Target:IC50: 0.15 μM (Malic enzyme).

Specifications and Purity: ≥99%

Molecular Formula: C20H21N3O3

Molecular Weight: 351.40

PubChem CID: 2936632

Isomeric SMILES: C1CN(CCN1C2CC(=O)N(C2=O)C3=CC=CC=C3)C4=CC=C(C=C4)O