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m1002

M1002

Catalog No.
C007B-374092
Manufacturer No.
M646453-5mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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M1002 is a hypoxia-inducible factor-2 ( HIF-2 ) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors.In VitroM1002 (10 μM: 24 h) enhances the expression of HIF-2 target

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M1002 is a hypoxia-inducible factor-2 ( HIF-2 ) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors.In VitroM1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy. M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: 786-O cells Concentration: 10 μM Incubation Time: 24 hours Result: Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control. RT-PCRCell Line: Hep3B cells Concentration: 5 μM Incubation Time: 24 hours Result: Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.Form:Solid.

Specifications and Purity: ≥99%

Molecular Formula: C15H8F6N2O2S

Molecular Weight: 394.29

UPC:
41113402
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
M646453-5mg
CAS:
823830-85-9
Product Size:
5mg

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