LYS-DES-ARG9-BRADYKININ

Amino Acid Sequence

Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

Application

[Lys-des-Arg9]-Bradykinin has been used as a B1R agonist to investigate the role of B1R in diabetes-induced secondary hemorrhage.

Biochem/physiol Actions

[Des-Arg10]-kallidin or [Lys-des-Arg9]-Bradykinin is a bradykinin B1 receptor agonist. It strongly upregulates the B1 receptor and is blocked by a specific protein kinase C inhibitor. The upregulation is correlated with the induction of transcription nuclear factor κB (NF-κB). Elevation of Lys-des[Arg9]–bradykinin because of airway inflammation in asthma patients is known to modify the immune responses. It affects the migration and production of interleukin-12 in monocyte-derived dendritic cells.

Other Notes

Lyophilized from 0.1% TFA in H2O

Molecular Weight: 1032.20. Empirical Formula: C₅₀H₇₃N₁₃O₁₁. Quality Level: 200. Assay: ≥. 95% (HPLC). form: powder. UniProt accession no.: P01042. storage temp.: −. 20°C. SMILES string: NCCCC[C@H](N)C(: O)N[C@@H](CCCNC(N): N)C(: O)N1CCC[C@H]1C(: O)N2CCC[C@H]2C(: O)NCC(: O)N[C@@H](Cc3ccccc3)C(: O)N[C@@H](CO)C(: O)N4CCC[C@H]4C(: O)N[C@@H](Cc5ccccc5)C(O): O. InChI: 1S/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1. InChI key: AILVBOHFGXNHCC-TZPCGENMSA-N. Gene Information: human ... KNG1 (includes EG:3827)(3827). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).