LY3000328 (C005B-309328)

Catalog No.: C005B-309328
Manufacturer No.: SML3229-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: EA

Biochem/physiol Actions LY3000328 is an orally active, non-covalent, potent and selective cathepsin S (Cat S, Cat-S, CatS, CTSS) inhibitor (human/mouse CatS IC50 = 7.7/1.

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Description
Specifications

Biochem/physiol Actions

LY3000328 is an orally active, non-covalent, potent and selective cathepsin S (Cat S, Cat-S, CatS, CTSS) inhibitor (human/mouse CatS IC50 = 7.7/1.67 nM) that targets the S2 and S3 subsites without interacting with the active site Cys25. LY3000328 prevents high glucose-induced human aortic smooth muscle cells (SMCs) osteogenic transformation in cultures (1 µM) and displays in vivo therapeutic efficacy in murine models of CaCl2-induced abdominal aortic aneurysm (AAA) (1-10 mg/kg bid po) and CD4+ T cell-mediated colitis induction (0.1 mg/0.2 mL/mouse via daily i.p.).

UPC:: 41114502
Condition:: New
HazmatClass:: No
MPN:: SML3229-5MG
CAS:: 1373215-15-6

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