InformationLoureirin B Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the K ATP current, influx of Ca 2+ to the intracellular.Targetsp-ERK ; p-JNK ; Calcium Channel ; Potassium Channel ; PAI-1 (Cell-free assay) ; 26.10 μM.
Specifications and Purity: 10mM in DMSO
Molecular Formula: C18H20O5
Molecular Weight: 316.35
PubChem CID: 189670
Isomeric SMILES: COC1=CC(=C(C(=C1)OC)CCC(=O)C2=CC=C(C=C2)O)OC
- UPC:
- 51131507
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- L420857-1ml
- CAS:
- 119425-90-0
- Product Size:
- 1ml
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