LINOLEIC ACID FREE ACID CELL CULTURE TESTED (C005B-051537)

General description

Linoleic acid (LA) is the precursor for the synthesis of arachidonic prostaglandins and other eicosanoids. LA is present in vegetable oils and meat.

Application

Fatty acid that is typically bound to a carrier molecule such as BSA or cyclodextrin for use in cell culture.

Linoleic acid has been used as a component of S12 medium for cardiomyocytes differentiation, minimum essential medium α for spermatogonial stem cell culture and for endothelial differentiation of mouse adipose-derived stem cells (mASC).

Biochem/physiol Actions

Linoleic acid (LA) may improve wound healing in diabetic rat. The levels of LA in adipose tissue and platelets are correlated with coronary artery disease. It may induce tumor and apoptosis in colorectal cancer cells. Studies also support their protective effects in lymphocytes. Linoleic acid is typically bound to a carrier molecule such as bovine serum albumin (BSA) or cyclodextrin for use in cell culture.

Linoleic acid increases cell proliferation and gene expression of PPARα and its target genes such as acyl-CoA oxidase in primary duck hepatocytes .

Packaging

Sealed ampule.

Molecular Weight: 280.45. Empirical Formula: C₁₈H₃₂O₂. linearFormula: CH₃(CH₂)₄CH: CHCH₂CH: CH(CH₂)₇CO₂H. biological source: plant (Safflower oil). Quality Level: 200. product line: BioReagent. Assay: ≥. 99%. form: liquid. technique(s): cell culture | mammalian: suitable. refractive index: n20/D 1.466 (lit.). bp: 229-230 . °C/16 . mmHg (lit.). mp: −. 5 . °C (lit.). solubility: NaOH: 1 . M, ethanol: soluble. density: 0.902 . g/mL . at 25 . °C (lit.). web metadata keyword.default: PUFA, omega-6 fatty acid, arachidonic acid precursor. storage temp.: −. 20°C. SMILES string: OC(CCCCCCC/C: C\C/C: C\CCCCC): O. InChI: 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-. InChI key: OYHQOLUKZRVURQ-HZJYTTRNSA-N. Gene Information: human ... SOAT1(6646), SOAT2(8435). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US).