LB-100 (C007B-203757)

InformationLB-100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.TargetsPP2AIn vitroLB-100 inhibits the cell growth with IC50 of 2.3 μM (in BxPc-3) or 1.7 μM (in Panc-1 cell). In BxPc-3, Panc-1, and SW1990 cells, LB-100 reduces the PP2A activity by 30-50%. LB-100 increases concentration of doxorubicin within cells (2.5 fold to control) and sensitizes tumor cells to the cytotoxicity of doxorubicin. LB-100 increaseds VEGF secretion, and thus enhances HIF-1α-VEGF mediated angiogenesis.In vivoIn a mouse pancreatic cancer xenograft model, LB-100 (2 mg/kg, i.p.) enhances chemotherapy of doxorubicin. LB-100 causes higher density of microvessel in tumors and rapid blood flow at the surface of tumors.Cell Research(from reference)Cell lines：BxPc-3, and Panc-1 cell lines Concentrations：~ 10 μM Incubation Time：48 h.

Specifications and Purity: 10mM in Water

Molecular Formula: C13H20N2O4

Molecular Weight: 268.31

PubChem CID: 3578572

Isomeric SMILES: CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3