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Biochem/physiol Actions trans-22a is the inactive trans-isomer of and negative control for the potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor cis-22a (Cd 2+ influx IC50 = 3.13 &#956:M/trans-22a vs.

Biochem/physiol Actions trans-22a is the inactive trans-isomer of and negative control for the potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor cis-22a (Cd 2+ influx IC50 = 3.13 &#956:M/trans-22a vs.

Biochem/physiol Actions MR6-31-2, a CNS penetrant ebselen analog, is a potent inhibitor of SARS-CoV-2 Mpro that bind at the Mpro catalytic site. MR6-31-2 donates a selenium atom, forming a covalent bond and blocking the histidine-Cys catalytic

Biochem/physiol Actions MR6-31-2, a CNS penetrant ebselen analog, is a potent inhibitor of SARS-CoV-2 Mpro that bind at the Mpro catalytic site. MR6-31-2 donates a selenium atom, forming a covalent bond and blocking the histidine-Cys catalytic

Biochem/physiol Actions NR-160 is an active site-targeting, potent and selective histone deacetylase 6 inhibitor (HDAC6 IC50 = 30 nM: IC50 &gt:2 &#956:M against HDAC1/2/3/4/8) that upregulates HL60 cellular acetylation of HDAC6 substrate

Biochem/physiol Actions NR-160 is an active site-targeting, potent and selective histone deacetylase 6 inhibitor (HDAC6 IC50 = 30 nM: IC50 &gt:2 &#956:M against HDAC1/2/3/4/8) that upregulates HL60 cellular acetylation of HDAC6 substrate

Biochem/physiol Actions There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer.

Biochem/physiol Actions Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes

General description Chemical structure: peptide Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The &#945:-defensins are distinguished

General description SDF-1&#945: (stromal cell-derived factor 1 &#945:) and &#946: are stromal derived CXC chemokines, and signal through the CXCR4 (C-X-C motif chemokine receptor). SDF1&#945: is an isoform of CXCL12 (C-X-C motif chemokine 12,

General description AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis. AMPK exists as a heterotrimeric complex composed of a catalytic &#945: subunit and regulatory &#946: and &#947:

General description This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the