Inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells (IC<sub>50</sub> values of 90 and 79 nM, respectively) inhibits cholesterol biosynthesis in rats reducing both cholesterol and triglyceride levels in plasma.
Inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells (IC<sub>50</sub> values of 90 and 79 nM, respectively) inhibits cholesterol biosynthesis in rats reducing both cholesterol and triglyceride levels in plasma.
A selective, cell-permeable EZH2 inhibitor (IC<sub>50</sub> = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC<sub>50</sub> value of 124 nM.
A selective, cell-permeable EZH2 inhibitor (IC<sub>50</sub> = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC<sub>50</sub> value of 124 nM.
A selective inhibitor of Aurora B kinase (IC<sub>50 </sub>= 10 µM), less potently inhibiting Aurora C and A (IC<sub>50</sub> = 250 and 1,000 nM, respectively) has been used to study the role of Aurora B in molecular events associated with
A selective inhibitor of Aurora B kinase (IC<sub>50 </sub>= 10 µM), less potently inhibiting Aurora C and A (IC<sub>50</sub> = 250 and 1,000 nM, respectively) has been used to study the role of Aurora B in molecular events associated with
A selective, cell-permeable EZH2 inhibitor (IC<sub>50</sub> = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC<sub>50</sub> value of 124 nM.
A selective, cell-permeable EZH2 inhibitor (IC<sub>50</sub> = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC<sub>50</sub> value of 124 nM.
A selective inhibitor of Aurora B kinase (IC<sub>50 </sub>= 10 µM), less potently inhibiting Aurora C and A (IC<sub>50</sub> = 250 and 1,000 nM, respectively) has been used to study the role of Aurora B in molecular events associated with
A selective inhibitor of Aurora B kinase (IC<sub>50 </sub>= 10 µM), less potently inhibiting Aurora C and A (IC<sub>50</sub> = 250 and 1,000 nM, respectively) has been used to study the role of Aurora B in molecular events associated with
An agonist of GPR199 that is effective both in isolated cells and in vivo increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 &muM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg).
An agonist of GPR199 that is effective both in isolated cells and in vivo increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 &muM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg).
A selective, cell-permeable EZH2 inhibitor (IC<sub>50</sub> = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC<sub>50</sub> value of 124 nM.
A selective, cell-permeable EZH2 inhibitor (IC<sub>50</sub> = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC<sub>50</sub> value of 124 nM.