L-Moses dihydrochloride (C007B-365135)

L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM.Appearance:SolidIC50& Target:Brd 126 nM (Kd)In Vitro:L-Moses (L-45) disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-Moses with the homologous Brd Pf GCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. AIn Vivo:L-Moses (L-45) shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use. MCE has not independently conBiological Activity:L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM.

Molecular Formula: C21H26Cl2N6

Molecular Weight: 433.38