Ku80 Mouse mAb (C007B-027002)

Application:WB: 1/500 - 1/2000. Detects a band of approximately 86 kDa (predicted molecular weight: 83 kDa). IHC: 1/200 - 1/1000 IF/ICC: 1/200 - 1/1000 Flow: 1/200 - 1/400ELISA: 1/10000The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Specifications and Purity: ExactAb™, Validated, Carrier Free, 1.0 mg/mL