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kt 5720

KT 5720

Catalog No.
C005B-006638
Manufacturer No.
K3761-.1MG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
MG

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Application KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2

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Application

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

Biochem/physiol Actions

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Molecular Weight: 537.61. Empirical Formula: C32H31N3O5. biological source: microbial. Quality Level: 200. Assay: ≥. 98% (HPLC). form: powder. color: white to faint yellow. solubility: methanol: 5 . mg/mL. shipped in: wet ice. storage temp.: −. 20°C. SMILES string: CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C: CC: C4): C4C5: C3C6: C(C(C: CC: C7): C7N6[C@]1(C)O2)C8: C5C(NC8): O): O. InChI: 1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1. InChI key: ZHEHVZXPFVXKEY-IKZDWWSZSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
41116106
Condition:
New
HazmatClass:
No
MPN:
K3761-.1MG
CAS:
108068-98-0
Temperature Control Device:
Yes

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