KOLLIPHOR(R) P 188 SOLID (C005B-002491)

General description

Kolliphor^® P 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.

Application

Kolliphor^® P 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.

Kolliphor^® P 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage.

Biochem/physiol Actions

Kolliphor^® P 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe²⁺ and H₂O₂.

Legal Information

Kolliphor is a registered trademark of BASF

Lutrol is a registered trademark of BASF SE

Agency: USP/NF, meets USP testing specifications. Quality Level: 200. form: solid. mol wt: 8.400 . g/mol. pH: 5.0-7.5(2.5% solution). application(s): sample preservation. InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3. 1-2-3-1/h3H,2H2,1H3. 1-2H2. InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1.