Kobusin (C007B-363287)

Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.In VitroKobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Formula: C21H22O6

Molecular Weight: 370.4

PubChem CID: 182278

Isomeric SMILES: COC1=C(C=C(C=C1)[C@@H]2[C@H]3CO[C@@H]([C@H]3CO2)C4=CC5=C(C=C4)OCO5)OC