KITALYSIS(TM) HIGH-THROUGHPUT MIYUARA BORYLATION REACTIONSCREENING KIT-PACK OF 2

General description

The KitAlysis High-Throughput Miyaura Borylation Reaction Screening Kit enables chemists to quickly and efficiently screen reaction conditions for Pd catalyzed Miyaura borylation reactions. Quick identification of optimal conditions allows faster scale-up of the desired synthetic transformation. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Miyaura Borylation Reaction Screening Kit
Downloadable Experiment excel sheets

Each kit contains 2 customizable screening sets that include the following components:

• 6 x 4 pre-weighed catalysts in glass vials loaded with stir bars and topped with cap mat.
• 4 x 4 mL reaction vials with pre-weighed KOAc
• Bis(pinacolato)diboron (473294), tetrahydroxydiboron (754242), and pinacol (221171)
• 1 (2 mL) ampule each of toluene, THF, n-butanol, DMA, MeOH, MeCN, ethylene glycol and DIPEA.
• 1 NEW KitAlysis 24-Well Reaction Block Replacement Film.
• 4 stir bars for substrate stock solution vials.
• 1 internal standard.

Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

• Designed and tested by synthetic chemists.
• Easily run 24-microscale reactions in parallel.
• 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration.
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

reaction suitability: reagent type: catalyst
core: palladium
reaction type: Miyaura Borylation Reaction. functional group: phosphine. Pictograms: GHS02,GHS05,GHS06,GHS08,GHS09. Signal Word: Danger. Hazard Statements: H225 - H301 + H311 + H331 - H315 - H318 - H335 - H336 - H351 - H360D - H370 - H373 - H410. Precautionary Statements: P210 - P273 - P280 - P301 + P310 - P303 + P361 + P353 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 1. Target Organs: Kidney. Supp Hazards: EUH019. Storage Class Code: 3 - Flammable liquids. WGK: WGK 3. Flash Point(F): 1.4 °F. Flash Point(C): -17 °C.