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kb02-jq1 (c09-1141-259)

KB02-JQ1 (C007B-363312)

Catalog No.
C007B-363312
Manufacturer No.
K646950-5mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3 . KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation

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KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3 . KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1In VitroKB02-JQ1 (5-40 μM; 24 hours; HEK293T cells) treatment shows concentration-dependent degradation of endogenous BRD4 in HEK293T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HEK293T cells Concentration: 5 μM, 10 μM, 20 Μm or 40 μM Incubation Time: 24 hours Result: Concentration-dependent degradation of endogenous BRD4 in HEK293T cells.Form:SolidIC50& Target:BRD4.

Specifications and Purity: ≥98%

Molecular Formula: C38H43Cl2N7O6S

Molecular Weight: 796.76

PubChem CID: 137347731

UPC:
12141804
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
K646950-5mg
CAS:
2384184-44-3
Product Size:
5mg

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