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k-252a (c15-1295-213)

K252A READY-MADE SOLUTION FROM NONOMURAEA LONGICATENA (C005B-092503)

Catalog No.
C005B-092503
Manufacturer No.
K2015-200UL
Manufacturer Name
Sigma-Aldrich
Quantity
200
Unit of Measure
UL

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Biochem/physiol Actions K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of

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Biochem/physiol Actions

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Features and Benefits

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physical form

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

Molecular Weight: 467.47. Empirical Formula: C27H21N3O5. biological source: Nonomuraea longicatena. Quality Level: 200. Assay: >. 98%. form: solution. shipped in: dry ice. storage temp.: −. 20°C. SMILES string: [H][C@]12C[C@](O)(C(: O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(: O)c6c7c8ccccc8n2c7c35. InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1. InChI key: KOZFSFOOLUUIGY-SOLYNIJKSA-N. Gene Information: human ... NTRK1(4914)
rat ... Prkca(24680). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): 188.6 °F - closed cup. Flash Point(C): 87 °C - closed cup. Personal Protective Equipment: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US).
UPC:
12141804
Condition:
New
HazmatClass:
Yes
MPN:
K2015-200UL
CAS:
99533-80-9
Temperature Control Device:
Yes

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