Biochem/physiol Actions
JNK2 is a member of the JNK family that acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK2 targets specific transcription factors, and mediates immediate-early gene expression in response to various cell stimuli. Both UV radiation and the proinflammatory cytokine TNFα can induce JNK2. JNK2 play a main role in the regulation of regional specific apoptosis during early brain development and providing protection against autoimmune diabetes.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
- UPC:
- 41106614
- Condition:
- New
- HazmatClass:
- No
- MPN:
- SRP5042-10UG
- Temperature Control Device:
- Yes
akash.verma@cenmed.com
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