JAK-IN-23 (C007B-363144)

JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB . JAK-IN-23 can inhibit JAK1/2/3 with IC 50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NFAppearance:SolidIC50& Target:JAK1 8.9 nM (IC 50 ) JAK2 15 nM (IC 50 ) JAK3 46.2 nM (IC 50 ) NF-κB 150.7 nM (IC 50 ) ISG 3.3 nM (IC 50 )In Vitro:JAK-IN-23 inhibits JAK1/2/3 with IC 50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 shows potent inhibitory activities against ISG and NF-KB with IC 50 values of 3.3 nM and 150.7 nM, respectively. WB--- JAK-IN-23 (0.33μM, 1μM, 3μIn Vivo:JAK-IN-23 (1-5mg/kg, oral) produces a strong anti-inflammatory activity in both dextran sulfate sodium (DSS) - and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute enteritis models and restores the structural composition of gut microbiota. MCBiological Activity:JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB . JAK-IN-23 can inhibit JAK1/2/3 with IC 50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF.

Specifications and Purity: ≥98%

Molecular Formula: C23H22Cl2N4O

Molecular Weight: 441.35