JAK/HDAC-IN-1 (C007B-363052)

JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC 50 s of 4 and 2 nM for JAK2 and HDAC , respectivelyIn VitroJAK/HDAC-IN-1 (Compound 8m) exhibits IC 50 s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:JAK2 4 nM (IC 50 ) JAK1 4.8 nM (IC 50 ) JAK3 7.4 nM (IC 50 ) Tyk2 49 nM (IC 50 ) HDAC 2 nM (IC 50 ) HDAC2 14 nM (IC 50 ) HDAC6 120 nM (IC 50 ) HDAC8 2470 nM (IC 50 ).

Specifications and Purity: ≥98%

Molecular Formula: C19H21Cl2N7O2

Molecular Weight: 450.3

PubChem CID: 138377596

Isomeric SMILES: C1=CC(=CC=C1NC2=NC(=NC=C2Cl)NC3=CN(N=C3)CCCCCC(=O)NO)Cl