Isoxazole 9 (ISX-9) (C007B-196329)

InformationIsoxazole 9 (ISX-9) Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelialIn vitroIn NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs.In vivoIn mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory.Cell Datacell lines：MKN45, EBC-1, Hs746T, SNU-5, A549, SNU-1 and MKN74Concentrations：~50 μMIncubation Time：48 hPowder Purity:≥98%.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C11H10N2O2S

Molecular Weight: 234.27