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interleukin-2 soluble receptor alpha human

INTERLEUKIN 2 SOLUBLE RECEPTOR ALPHA (IL-2 R ALPHA) RECOMBINANT HUMAN

Catalog No.
C005B-223323
Manufacturer No.
I0779-5UG
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
UG

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Biochem/physiol Actions Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance.

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Biochem/physiol Actions

Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Analysis Note

The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.

biological source: human. Quality Level: 200. recombinant: expressed in NSO cells. Assay: >. 97% (SDS-PAGE). form: lyophilized powder. potency: 0.5-1.0 . mg per mL ED50. mol wt: 36 . kDa by SDS-PAGE. packaging: pkg of 5 . μ. g. impurities: endotoxin, tested. UniProt accession no.: P01589. storage temp.: −. 20°C. Gene Information: human ... IL2RA(3559). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
51182014
Condition:
New
HazmatClass:
No
MPN:
I0779-5UG

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