INTERFERON ALPHA A HUMAN RECOMBINANT

Application

Interferon-αA human has been used to:

• study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
• study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
• compare the effect of Monascus pigment derivatives on hepatitis C virus replication

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Physical form

Supplied as a solution in 5 mM sodium acetate, pH 4.0.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.

biological source: human. Quality Level: 200. recombinant: expressed in E. coli. Assay: ≥. 95%. form: buffered aqueous solution. mol wt: 19 . kDa. packaging: pkg of 20 . μ. g. concentration: ≥. 0.2 . mg/mL. technique(s): cell culture | mammalian: suitable. impurities: endotoxin, tested. color: colorless. UniProt accession no.: P01563. shipped in: wet ice. storage temp.: −. 20°C. Gene Information: human ... IFNA2(3440). Storage Class Code: 10 - Combustible liquids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves.