INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-2 RECOMBINANT MOUSE

General description

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.

Physical form

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

biological source: mouse. Quality Level: 200. recombinant: expressed in NSO cells. Assay: ≥. 95% (SDS-PAGE). form: lyophilized powder. potency: 0.125-0.5 . mg per mL ED₅₀. mol wt: ~35 . kDa by SDS-PAGE (reducing), calculated mol wt 29.4 . kDa. packaging: pkg of 25 . μ. g. technique(s): cell culture | mammalian: suitable. impurities: endotoxin, tested. UniProt accession no.: D3YU40. storage temp.: −. 20°C. Gene Information: mouse ... Igfbp2(16008). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).