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indomethacin (c15-1247-034)

INDOMETHACIN MEETS USP TESTING SPECIFICATIONS (C005B-047392)

Catalog No.
C005B-047392
Manufacturer No.
I8280-5G
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
GR

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Biochem/physiol Actions Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1. Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

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Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

Molecular Weight: 357.79. Empirical Formula: C19H16ClNO4. Agency: USP/NF, meets USP testing specifications. Quality Level: 200. Assay: 98.0-102.0%. form: powder. Mode of action: enzyme | inhibits. SMILES string: COc1ccc2n(c(C)c(CC(O): O)c2c1)C(: O)c3ccc(Cl)cc3. InChI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23). InChI key: CGIGDMFJXJATDK-UHFFFAOYSA-N. Gene Information: human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527). Pictograms: GHS06. Signal Word: Danger. Hazard Statements: H300. Precautionary Statements: P264 - P301 + P310. Hazard Classifications: Acute Tox. 1 Oral. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges.
UPC:
51111704
Condition:
New
HazmatClass:
Yes
MPN:
I8280-5G
CAS:
53-86-1
Temperature Control Device:
Yes

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