Immunoglobulin G (IgG), Normal Human Plasma (C007B-551380)

IgG is the most abundant immunoglobulin in plasma, found at a concentration of 8 to 18 mg/ml. This immunoglobulin plays a very important role in the defense against infection for newborns because of its transfer through the placenta during pregnancy. It readily diffuses into the extravascular body spaces where it plays a major role in neutralizing bacterial toxins and in enhancing the phagocytosis of microorganisms. IgG binds to bacteria and these complexes adhere to phagocytic cells which have surface receptors specific for IgG.Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.Product Citations:Baković, Maja Pučić, et al. "High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides." Journal of proteome research 12, no. 2 (2013): 821-831Smith, Loren E., et al. "Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins CI and A-II." Journal of lipid research 54, no. 7 (2013): 1939-1948.Lee, Kyoung Ho, et al. "Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering." Applied microbiology and biotechnology(2013): 1-11.Dolfi, Douglas V., et al. "Vaccine-Induced Boosting of Influenza Virus-Specific CD4 T Cells in Younger and Aged Humans." PLOS ONE 8, no. 10 (2013): e77164.Herati RS, et al. Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults. J Immunol. 2014 Oct 1;193(7):3528-37. doi: 10.4049/jimmunol.1302503. Epub 2014 Aug 29.Fletcher NA, Von Nieda EL, Krebs MD. Cell-interactive alginate-chitosan biopolymer systems with tunable mechanics and antibody release rates.Carbohydrate Polymers, In press 15 August 2017.Kammeijer GS, Kohler I, Jansen BC, Hensbergen PJ, Mayboroda OA, Falck D, Wuhrer M. Dopant Enriched Nitrogen Gas Combined with Sheathless Capillary Electrophoresis–Electrospray Ionization-Mass Spectrometry for Improved Sensitivity and Repeatability in Glycopeptide Analysis.Anal Chem. 2016 Jun 7;88(11):5849-56. doi: 10.1021/acs.analchem.6b00479. Epub 2016 May 12.Fletcher NA, Babcock LR, Murray EA, Krebs MD. Controlled delivery of antibodies from injectable hydrogels. Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:801-806. doi: 10.1016/j.msec.2015.10.096. Epub 2015 Oct 30.Fokkink WJR, et al. Comparison of Fc N-Glycosylation of Pharmaceutical Products of Intravenous Immunoglobulin G. PLoS One. 2015 Oct 12;10(10):e0139828. doi: 10.1371/journal.pone.0139828. eCollection 2015.Tercero N, Kotarek J. Voltammetric Monitoring of Protein Aggregation from Solution Using Tris-(2,2′-Bipyridine) Osmium(II) Chloride Complex as an Electrocatalytic Mediator. Electroanalysis Volume 26, Issue 2 pgs 243-247. 29 JAN 2014 | DOI: 10.1002/elan.20130046.Ramadass M, Ghebrehiwet B, Smith RJ, Kew RR. Generation of Multiple Fluid-Phase C3b:Plasma Protein Complexes during Complement Activation: Possible Implications in C3 Glomerulopathies. J Immunol. 2014 Feb 1;192(3):1220-30. doi: 10.4049/jimmunol.1302288. Epub 2013 Dec 23.Swisher JFA, et al. IgG4 can induce an M2-like phenotype in human monocyte-derived macrophages through FcγRI. MAbs. 2014;6(6):1377-84. doi: 10.4161/19420862.2014.975657.Ref:Deisenhofer. J. 1981. Biochemistry. 20, 2361; Mehl, V.S. and Penn, G.M. 1986. Manual of Clinical Laboratory Immunology (N.R. Rose, ed.), 126.

Specification: ≥95%(SDS-PAGE), Extinction Coefficient: 1.36