IITZ-01 (C005B-310370)

Catalog No.: C005B-310370
Manufacturer No.: SML2631-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Biochem/physiol Actions IITZ-01 is a cell penetrant and potent autophagy inhibitor in numerous cancer cells including breast, lung, and colon cancer cells. It significantly elevates LC3-II and SQSTM1 protein levels in starvation-induced autophagy

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Description
Specifications

Biochem/physiol Actions

IITZ-01 is a cell penetrant and potent autophagy inhibitor in numerous cancer cells including breast, lung, and colon cancer cells. It significantly elevates LC3-II and SQSTM1 protein levels in starvation-induced autophagy conditions. IITZ-01 accumulates within lysosomes causing liposomal deacidification, impairment of lysosomal maturation and inhibition of lysosomal degradation. Additionally, IITZ-01 induces apoptosis through the mitochondria-mediated pathway in TNBC cells MDA-MB-231 and MDA-MB-453, while sparing normal mammary epithelial MCF10A cell.

UPC:: 41113621
Condition:: New
HazmatClass:: No
MPN:: SML2631-25MG
CAS:: 1807988-47-1

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