ICI 192605

Biochem/physiol Actions

ICI 192605 is a potent thromboxane A2 receptor antagonist. It inhibits platelet aggregation and can reverse the effects of vasoconstrictors such as TXA2 or PGD2. ICI 192605 can reverse vasoconstriction induced by inhibition of NO production by L-NEMA, which leads to an increase in TXA2 release.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 402.87. Empirical Formula: C₂₂H₂₃ClO₅. Quality Level: 100. Assay: ≥. 98% (HPLC). form: powder. color: white to tan. solubility: DMSO: ≥. 20 . mg/mL. originator: AstraZeneca. storage temp.: −. 20°C. SMILES string: OC(: O)CC\C: C/C[C@H]1CO[C@H](O[C@H]1c2ccccc2O)c3ccccc3Cl. InChI: 1S/C22H23ClO5/c23-18-11-6-4-9-16(18)22-27-14-15(8-2-1-3-13-20(25)26)21(28-22)17-10-5-7-12-19(17)24/h1-2,4-7,9-12,15,21-22,24H,3,8,13-14H2,(H,25,26)/b2-1-/t15-,21+,22+/m0/s1. InChI key: WHUIENZXNGAHQI-YGPRPMEGSA-N. Pictograms: GHS07,GHS09. Signal Word: Warning. Hazard Statements: H302 - H410. Precautionary Statements: P264 - P270 - P273 - P301 + P312 - P391 - P501. Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.