ICAM-1-IN-1 (C007B-362210)

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC 50 values of 7 and 5 nM, respectively.In VivoICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 7 nM (E-selectin), 5 nM (ICAM-1).

Specifications and Purity: ≥99%

Molecular Formula: C15H11BrN2O2S

Molecular Weight: 363.23

PubChem CID: 10361323

Isomeric SMILES: CNC(=O)C1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)Br