IBR2 (C005B-310960)

Catalog No.: C005B-310960
Manufacturer No.: SML2257-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Biochem/physiol Actions IBR2 is a cell penetrant, potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair and enhances cytotoxicity of multiple anticancer agents with disparate biochemical targets including

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Description
Specifications

Biochem/physiol Actions

IBR2 is a cell penetrant, potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair and enhances cytotoxicity of multiple anticancer agents with disparate biochemical targets including the Bcr-Abl inhibitor imatinib and multiple kinase inhibitor regorafenib. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, reduces ionizing radiation-induced RAD51 foci formation, inhibits cancer cell growth and induces apoptosis.

UPC:: 41113318
Condition:: New
HazmatClass:: No
MPN:: SML2257-25MG
CAS:: 952739-54-7

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