IBR2 (C008B-264432)

IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosisIn VitroIBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC 50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC 50 of 14.8 μM. Form:SolidIC50& Target:RAD51

Specifications & Purity: IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosisIn VitroIBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC 50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC 50 of 14.8 μM. Form:SolidIC50& Target:RAD51

Grade: Moligand™

Molecular Formula: C24H20N2O2S

Molecular Weight: 400.5

PubChem CID: 4664423

Isomeric SMILES: C1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54

Storage Temperature: Store at -20°C;Argon charged

Shipped in: Ice chest + Ice pads