HYPERFORIN

General description

Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.

Application

Hyperforin may be used:

• as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
• to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
• as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay

Biochem/physiol Actions

Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.

Molecular Weight: 536.78. Empirical Formula: C₃₅H₅₂O₄. Quality Level: 100. Assay: ≥. 85% (HPLC). form: solution. storage temp.: −. 20°C. SMILES string: CC(C)C(: O)[C@@]12C(O): C(C\C: C(\C)C)C(: O)[C@@](C\C: C(/C)C)(C[C@H](C\C: C(\C)C)[C@@]1(C)CC\C: C(\C)C)C2: O. InChI: 1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1. InChI key: IWBJJCOKGLUQIZ-HQKKAZOISA-N. Pictograms: GHS02,GHS06,GHS08. Signal Word: Danger. Hazard Statements: H225 - H301 + H311 + H331 - H370. Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311. Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1. Target Organs: Eyes. Storage Class Code: 3 - Flammable liquids. WGK: WGK 2. Flash Point(F): 49.5 °F - closed cup. Flash Point(C): 9.7 °C - closed cup. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).