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hydroxy-peg4-t-butyl ester

HYDROXY-PEG4-T-BUTYL ESTER

Catalog No.
C005B-046139
Manufacturer No.
902586-1G
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
GR

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Application This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility

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Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Other Notes

Recruiting cytotoxic T cells to folate-receptor-positive cancer cells

Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology

High density orthogonal surface immobilization via photoactivated copper-free click chemistry

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Molecular Weight: 322.39. Empirical Formula: C15H30O7. Assay: ≥. 95%. form: liquid. reaction suitability: reagent type: cross-linking reagent. refractive index: n/D 1.4492. density: 1.04746 . g/mL. functional group: ester, hydroxyl. storage temp.: 2-8°C. SMILES string: O: C(OC(C)(C)C)CCOCCOCCOCCOCCO. InChI: 1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3. InChI key: FJRDXEGYAVAMLB-UHFFFAOYSA-N. Storage Class Code: 10 - Combustible liquids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
51111906
Condition:
New
HazmatClass:
No
MPN:
902586-1G
CAS:
518044-32-1
Temperature Control Device:
Yes

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