HS-276 (C005B-308667)

Catalog No.: C005B-308667
Manufacturer No.: SML3629-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: EA

Biochem/physiol Actions HS-276 is an orally active, potent and selective TGF-β:-activated kinase-1 (TAK-1: TAK1) inhibitor (Ki = 2.5 nM: IC50 = 8.

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Description
Specifications

Biochem/physiol Actions

HS-276 is an orally active, potent and selective TGF-β-activated kinase-1 (TAK-1; TAK1) inhibitor (Ki = 2.5 nM; IC50 = 8.25 nM) that significantly reduced cytokines production in THP-1 human macrophages upon LPS/IFNγ treatment (IC50 = 138 nM/TNF, 201 nM/IL-6, and 234 nM/IL-1β). HS-276 effectively attenuates arthritic-like symptoms in the CIA mouse rheumatoid arthritis (RA) model (10-30 mg/kg/d p.o. or 25 mg/kg/d i.p.).

UPC:: 41113404
Condition:: New
HazmatClass:: No
MPN:: SML3629-25MG
CAS:: 2767422-72-8

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