HONOKIOL (C005B-034833)

General description

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

Application

Honokiol has been used:

• to study its effects on plasmid hSirt3^102-399 deacetylation activity
• as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
• to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
• for intracerebroventricular (ICV) cannulation

Biochem/physiol Actions

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Features and Benefits

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Molecular Weight: 266.33. Empirical Formula: C₁₈H₁₈O₂. Quality Level: 100. Assay: ≥. 98% (HPLC). form: powder. storage condition: desiccated. solubility: DMSO: 36 . mg/mL. antibiotic activity spectrum: Gram-positive bacteria, neoplastics. Mode of action: DNA synthesis | interferes. storage temp.: 2-8°C. SMILES string: Oc1ccc(cc1CC: C)-c2cc(CC: C)ccc2O. InChI: 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2. InChI key: FVYXIJYOAGAUQK-UHFFFAOYSA-N. Pictograms: GHS05,GHS09. Signal Word: Danger. Hazard Statements: H318 - H411. Precautionary Statements: P273 - P280 - P305 + P351 + P338 - P391 - P501. Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.