HOE-140

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Tic-Oic-Arg

Biochem/physiol Actions

B₂ bradykinin receptors are present in the sensory neurons. Activation of B₂ receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B₂ bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain.

Molecular Weight: 1304.52. Empirical Formula: C₅₉H₈₉N₁₉O₁₃S. Quality Level: 200. Assay: ≥. 94%. storage temp.: −. 20°C. SMILES string: N[C@H](CCCNC(N): N)C(: O)N[C@@H](CCCNC(N): N)C(: O)N1CCC[C@H]1C(: O)N2C[C@H](O)C[C@H]2C(: O)NCC(: O)N[C@@H](Cc3cccs3)C(: O)N[C@@H](CO)C(: O)N4Cc5ccccc5C[C@@H]4C(: O)N6[C@H]7CCCC[C@H]7C[C@H]6C(: O)N[C@@H](CCCNC(N): N)C(O): O. InChI: 1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1. InChI key: QURWXBZNHXJZBE-SKXRKSCCSA-N. Gene Information: human ... BDKRB2(624)
mouse ... BDKRB2(12062)
rat ... BDKRB2(25245). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).