HEXAMETHYLPHOSPHORAMIDE ABSOLUTE OVER MOLECULAR SIEVE (H2O <=0.03%) >=98.0% (GC) (C005B-056898)

Application

Hexamethylphosphoramide can be used:

• As an additive to facilitate the enantioselective addition of alkyne to aldehydes to generate propargylic alcohols at room temperature.
• As a catalyst for the reversible-deactivation radical polymerization of methyl methacrylate with an alkyl iodide initiator to generate poly(methyl methacrylate)(PMMA).
• To facilitate the conversion of tetra-alkyl methanediphosphonates into (Z)-2-aryl-1-(2-cyanoethyl)ethenylphos-phonates.

Hexamethylphosphoramide is a dipolar co-solvent and an effective additive used in reactions like reduction of halides, deoxygenation of sulfones, halide olefin couplings and cleavage of carbon-sulfur bond.

Molecular Weight: 179.20. Empirical Formula: C₆H₁₈N₃OP. linearFormula: [(CH₃)₂N]₃PO. vapor density: 6.18 (vs air). Quality Level: 100. vapor pressure: 0.07 mmHg ( 25 °C). Assay: ≥. 98.0% (GC). form: liquid. quality: absolute, over molecular sieve (H₂O ≤. 0.03%). impurities: ≤. 0.03% H₂O (coulometric). refractive index: n20/D 1.459 (lit.). bp: 230-232 . °C/740 . mmHg (lit.). mp: 7 . °C (lit.). density: 1.03 . g/mL . at 25 . °C (lit.). SMILES string: CN(C)P(: O)(N(C)C)N(C)C. InChI: 1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3. InChI key: GNOIPBMMFNIUFM-UHFFFAOYSA-N. Pictograms: GHS05,GHS08. Signal Word: Danger. Hazard Statements: H314 - H340 - H350. Precautionary Statements: P202 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363. Hazard Classifications: Carc. 1B - Eye Dam. 1 - Muta. 1B - Skin Corr. 1C. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): 291.2 °F - closed cup. Flash Point(C): 144 °C - closed cup.