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heregulin-beta, egf domain human

HEREGULIN-BETA EGF DOMAIN RECOMBINANT

Catalog No.
C005B-200548
Manufacturer No.
H0786-100UG
Manufacturer Name
Sigma-Aldrich
Quantity
100
Unit of Measure
UG

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Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin. Biochem/physiol Actions Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases.

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General description

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Physical form

Solution in phosphate buffered saline containing 30% glycerol.

Analysis Note

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

biological source: human. Quality Level: 200. recombinant: expressed in E. coli. Assay: ≥. 80% (SDS-PAGE). form: buffered aqueous glycerol solution. mol wt: 185 . kDa. packaging: pkg of 100 . μ. g. storage condition: avoid repeated freeze/thaw cycles. UniProt accession no.: Q02297. shipped in: dry ice. storage temp.: −. 20°C. Gene Information: human ... NRG1(3084). Storage Class Code: 10 - Combustible liquids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
41106503
Condition:
New
HazmatClass:
No
MPN:
H0786-100UG
Temperature Control Device:
Yes

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