HERBIMYCIN A FROM STREPTOMYCES HYGROSCOPICUS (C005B-058194)

General description

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Biochem/physiol Actions

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Caution

Hygroscopic and photosensitive

Molecular Weight: 574.66. Empirical Formula: C₃₀H₄₂N₂O₉. biological source: Streptomyces hygroscopicus. Quality Level: 200. Assay: ≥. 95% (HPLC). form: powder. color: yellow. solubility: DMSO: 7.5 . mg/mL (DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.). antibiotic activity spectrum: viruses. Mode of action: enzyme | inhibits. storage temp.: −. 20°C. SMILES string: CO[C@H]1C[C@H](C)[C@@H](OC)C2: CC(: O)C: C(NC(: O)\C(C): C\C: C[C@H](OC)[C@@H](OC(N): O)\C(C): C\[C@H](C)[C@H]1OC)C2: O. InChI: 1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1. InChI key: MCAHMSDENAOJFZ-BVXDHVRPSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).