HDS 029 is a potent inhibitor of the ErbB receptor family (IC|50|values are 0.3, 0.5 and 1.1 nM for EGFR (ErbB1), ErbB-4 (ErbB4) and Neu (ErbB2) respectively). It inhibits EGF-induced EGFR (erbB1) autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC|50|values are 2.5 and 24 nM respectively).
Specifications and Purity: ≥95%
Molecular Formula: C17H11ClFN5O
Molecular Weight: 355.76
PubChem CID: 11566580
Isomeric SMILES: CC#CC(=O)NC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl
Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/H331458-SCI_6c3d10db7d64e355bef163f7d4e03629.pdf
- UPC:
- 12141602
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H331458-10mg
- CAS:
- 881001-19-0
- Product Size:
- 10mg
- Precautionary Statement Codes:
- P264
akash.verma@cenmed.com
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